Preliminary invitro anticancer activity studies of various extracts of mesua ferrea l. Seeds
DOI:
https://doi.org/10.61096/ijpar.v11.iss2.2022.55-60Keywords:
EAC, PEE, EAE, ELE, CFEAbstract
Cancer is a major life threatening disease in both developed and developing countries. The agents which reversed or suppressed tumor progression are termed as anticancer agents. Various studies proved the advantages of natural anticancer agents over synthetic anticancer drugs.Mesua ferrea L. is an ornamental plant and is seen in Asian countries like India, Sreelanka, Andaman Islands, Myanmar, Indo-china, Thailand, Malaysia and Singapore. It is an ornamental tree with reddish brown to grey colored bark. Its leaves are initially red in color and then changes to pale green when it is matured. It is having a white color with floral fragrant flowers which contains numerous golden colored stamens. The flower buds having different medicinal properties against fever, sweats, foul breath, bleeding disorders, small tumors, snake bite etc.The seed oil which was isolated from Mesua ferrea wasused for skin diseases like itching, dandruff, skin eruptions etc. The flowers were used for dysentery, bleeding disorders, rheumatism and iron induced lipid peroxidation. Seed decoctions of this plant were used for gastritis, bronchitis and for curing snake bite. Preliminary screening of various extracts of Mesua Ferrea L. seeds proved the presence of various active principles and also showing antioxidant potentials. On the basis of these preliminary studies invitro anticancer activity screening of four extracts of Mesua ferrea L. seeds were carried out using Trypan blue assay method. Here the cell line used was EAC cell line. Among the four extracts chloroform and petroleum ether extracts showed more prominent cytotoxicity.