Formulation and evaluation of alginate microspheres of pramipexole HCL

Abstract

The present work was designed to formulate and evaluate the Pramipexole microspheres. Drugs with short half-life frequent administration of dosage form is required, so the possible way by which this can be overcome by preparing sustained release microspheres of Pramipexole which can also improve patient compliance. The alginate microspheres were prepared by ionotropic gelation technique. Sodium alginate and chitosan were used as polymers, calcium chloride as cross-linking agent, and Olibanum gum is also used. Microspheres were characterized for the Micromeritic properties, incorporation efficiency, Swelling Index, SEM analysis, FTIR, and in vitro release studies. Among all formulations S14 was optimized on the basis of different evaluation parameters. The % yield of S14 formulation was found to be 96.41 %, entrapment efficiency and swelling index of S14 formulation was 95.26%, 97% respectively. The Cumulative % drug release of S14 formulation was 97.19±5.10% in 12h when compared with marketed product 90.45±5.10 in 12hrs. SEM studies showed the particles were in spherical shape. The method developed in the present study can be effectively utilized to achieve the formulation with desired release characteristics in the effective management of Parkinson’s disease.