In vivo evaluation of lamivudine extended release trilayer matrix tablets
DOI:
https://doi.org/10.61096/ijpar.v7.iss3.2018.233-245Keywords:
Lamivudine, AIDS, Trilayer matrix tablet, Xanthan gum, Geomatrix, Bioavailability studiesAbstract
The objective of the present study was aimed to develop and optimize extended release (ER) matrix tablets of Lamivudine trilayer tablets by direct compression and consist of middle active layer and barrier layers were prepared with different concentrations of hydrophilic and hydrophobic polymers. The tablets were also evaluated for physicochemical characteristics and release kinetics. The physicochemical characteristics of the prepared tablets were satisfactory. The developed drug delivery systems showed prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (HF23) was described by the Zero-order and Higuchi model. From in vivo bioavailability studies, AUC0- inf for optimized formulation was higher than the marketed formulation. Statistically, AUC0-t of the optimized formulation was significantly higher (p<0.05) as compared to marketed formulation. The present study demonstrated that formulation of Lamivudine trilayer matrix tablet is a highly effective strategy for enhancing the prolonged drug release and bioavailability.