Formulation and evaluation of dabigatran fast dissolving tablets by using polyplasdone xl-10 and primellose

Authors

  • Ausaf Butool Sultan-ul-uloom College of Pharmacy, Banjara Hills, Hyderabad-500034, T.S
  • Bibi Fareesa Banu Sultan-ul-uloom College of Pharmacy, Banjara Hills, Hyderabad-500034, T.S
  • Tuba khan Sultan-ul-uloom College of Pharmacy, Banjara Hills, Hyderabad-500034, T.S
  • Rufaida Farheen Sultan-ul-uloom College of Pharmacy, Banjara Hills, Hyderabad-500034, T.S
  • Y Rajesh Associate Professor Dept. of Pharmaceutical chemistry, Sultan-ul-uloom College of Pharmacy

DOI:

https://doi.org/10.61096/ijpar.v7.iss3.2018.301-316

Keywords:

Dabigatran, Hydrophilic carriers, Fast Dissolvi ng tablets, Super-disintergants.

Abstract

Dabigatran is an oral anticoagulant drug requiring rapid onset of action to  exe rt desired pharmacological effect. It is a lipophilic (BCS Class-II) with little/no aqueous solubility, its absorption is dissolution rate limited. Increase in solubility of the drug is required to get rapid action. It has the half life of 14 hours and bioavailability in the body is 65% due to first pass metabolism. The purpose of this investigation is to develop fast dissolvimg tablet of Dabigatran to improve oral bioavailability for its immediate action for the treatment of  stroke  prevention  in  atrial  fibrillation,  the  fast  dissolving  tablet  was  formulated  by  wet  granulation technique  using  hydrophilic  carrier   like   PEG -400   as   solubilizer  and  POLYPLASDONE  XL-10   and PRIMELLOSE used as super-disintegrant. The pre and post compression parameters were evaluated. From the dissolution profile  it  was  concluded the  tablet  prepared by  wet  granulation technique, the  formulationF6 containing 4% of PEG 4000 and    7.5% PRIMELLOSE showed 85.46% drug release due to its increase in porosity and wettability. From the DSC and   FTIR study it was concluded that there was no possible drug and polymer interactions.

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Published

2022-09-07

How to Cite

Ausaf Butool, Bibi Fareesa Banu, Tuba khan, Rufaida Farheen, & Y Rajesh. (2022). Formulation and evaluation of dabigatran fast dissolving tablets by using polyplasdone xl-10 and primellose. IJPAR JOURNAL, 7(3), 301–316. https://doi.org/10.61096/ijpar.v7.iss3.2018.301-316