Impact of three square factorial design in formulation and characterization of mianserintransferosomes

Abstract

Objective

The current investigation deals with formulate and characterize the Mianserintransferosomes using 32   factorial design.

Method

Mianserin is a BCS class II drug and is widely preferred for the antidepressant action. The transferosomes are developed using thin film hydration method by varying the concentrations of lecithin: span 80 and Mianserin. A total of 9 formulations were developed by considering the ration of lecithin: span 80 and Mianserin as independent variables and assigned as X1 and X2 respectively and entrapment efficacy, drug content, and vesicle size as the dependent variables. Further, the results were subjected to response surface methodology using sigma plot® software and the statistical equations were drawn out.

Results

The generated results clarifies that the current formulations meet the pharmacopoeial standards and justifies F5 as the optimized formulation. When subjected to kinetic modeling F5 exhibited first order release kinetics with non-Fickian diffusion. Further the development of polynomial equations for dependent variables through step -wise backward non- linear regression analysis revealed the interaction between the selected variables and their effect on interchanging them.

Conclusion

The F5 is considered as optimized formulationand follows first order, and Higuchi kinetics, and the mechanism of drug release is found to be non-Fickian diffusion anomalous transport.