Refinement of solubility of Resperidone formulating as fast dissolving tablets using molecular dispersion technique

Abstract

The oral route is most common and preferred route for drug delivery system, it is convenient and easy ingestion. Solid dispersion techniques have been used to enhance the dissolution and oral bioavailability of many poorly soluble drugs .Hence the researchers focused on two areas i) To enhance solubility and dissolution ii) To increase the permeability of poorly water soluble drugs. Solid dispersion is containing at least two different components. Solid dispersion drug dissolves immediately to saturate the gastrointestinal tract (GIT) fluid, and excess drug precipitates as fine colloidal particles or oily globules of submicron to nano size Preparation of the soli dispersion can be done by the hot melt extrusion process and wet extrusion process. Various types of the materials are used in the preparation process they are carries, Emulsifiers, Cellulose Derivatives, Plasticizers and  some other equipment’s are  used  to  determine  the Risperidone’s solubility and dissolution profile is expected to significantly improve its bioavailability and reduce its side effects.