Synthesis, characterization and screening of anti convulsant activity of novel tetra substituted imidazole derivatives

Authors

  • Lincy Joseph Department of Pharmaceutical chemistry, Pushpagiri College of Pharmacy, Thiruvalla, Kerala
  • Akshay Murali Department of Pharmaceutical chemistry, Pushpagiri College of Pharmacy, Thiruvalla, Kerala
  • Mathew George Department of Pharmacology, Pushpagiri College of Pharmacy, Thiruvalla, Kerala

DOI:

https://doi.org/10.61096/ijpar.v7.iss3.2018.490-493

Keywords:

Tetra substituted imidazole, PTZ & MES method, Anti convulsant activity.

Abstract

In this study a new tetra substituted imidazole derivatives has been synthesized from the condensation of Benzil, substituted aldehyde, substituted aromatic amine and ammonium acetate in presence of glacial acetic acid at 120 -140 ºC. The newly synthesized derivatives has been characterized by various physicochemical techniques such as melting point, TLC, FTIR 1HNMR, and elemental analysis. The synthesized compounds are screened for their anti convulsant activity by PTZ induced convulsion and MES  method. The  standards used  for the  method are diazepam and phenytoin respectively.

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Published

2022-09-09

How to Cite

Lincy Joseph, Akshay Murali, & Mathew George. (2022). Synthesis, characterization and screening of anti convulsant activity of novel tetra substituted imidazole derivatives. IJPAR JOURNAL, 7(3), 490–493. https://doi.org/10.61096/ijpar.v7.iss3.2018.490-493