Formulation and evaluation of gastroretentive floating tablets of rebamipide

Abstract

The present study outlines a systematic approach for design and evaluate of Rebamipide floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. It was prepared based on wet granulation technique for sustained delivery of active agent. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Gastroretentive floating tablets, which was designed to provide the desired sustained and complete release of drug for prolonged period of time. Gastroretentive floating tablets of Rebamipide were prepared by wet granulation technique  using  different concentrations of  Gellan Gum,  Fenugreek Gum and  Karaya  Gum.  The optimized formulation (RF22) exhibited 99.17% drug release in 12 hrs, while the buoyancy lag time was 38 sec. In- vitro drug release kinetics was found to follow both the Zero order and the possible mechanism of Rebamipide release from the optimized formulation might be attributed to super case II transport mechanism. The Optimized formulation (RF22) showed no significant change in physical appearance, drug content, floating lag time, in vitro dissolution studies after 75% ± 5 % RH at 40s ± 20C relative humidity for 6 months.