Synthesis, Physical characterisation and Biological Evaluation of novel 1, 3- thiazolidine-2, 4-dione derivatives as ALR-2 inhibitors

Abstract

In our research we particularly designed some new 5- (substituted benzylidene)-3-(2-(morpholin-4-yl) ethyl)-1,3-thiazolidine-2,4-diones. The 5-arylidene moiety contained a phenyl ring bearing a different potential electron donating as well as electron withdrawinggroups, this was found to be a favorable feature for ALR-2 inhibition. The structures of newly synthesized compounds were confirmed by physical parameters like Melting point, solubility, chromatographic methods (TLC) and at last by Spectroscopic methods (IR, ¹HNMR and MS). The Antidiabeticactivity of synthesized compounds were carried out on Wistar rats using Pioglitazone as standard drug. Apart from this activity thiazolidine-2,4- diones derivatives found to have diverse pharmacological actions like anti-inflammatory, anti-microbial, anti-proliferative, antiviral, anticonvulsant, anti-cancer etc.