Formulation and invitro evaluation of floating matrix tablets of m itiglinide

Abstract

The floating matrix tablet of MITIGLINIDE (MTG) was prepared using the combination of release controlling polymer HPMC K15M and sodium alginate. The final optimization was done by applying 32   full  factorial designs, taking floating lag time (Flag), time to release 50% of drug (t50) and time to release 90% of drug (t90) as dependent factors. All the formulations were evaluated and results showed that M -3 formulation containing maximum amount of both variables gave promising results, hence was considered as optimized batch.A Gastroretentive multiparticulate system of MTG was developed as floating microsponges by quasi-emulsion solvent diffusion method. The primary screening of formulation related and process rel ated variables was done by trial and error technique. The final optimization of dosage form was done by applying 32 full factorial design by taking concentrations of PVA (X1) and EUDRGIT S 100(X2) as independent factors and product yield (Y 1), % entrapment efficiency (Y2), % buoyancy (Y3)