Formulation and evaluation of dipyridamole effervescent floating tablets

Abstract

In the present research work effervescent floating formulation of Dipyridamole by using various polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various natural polymers. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend hasgood flow properties. Among all the formulations the formulations prepared by using HPMC K15M were unable to produce desired drug release; they were unable to retard drug release up to 12 hours. The formulations prepared with Guar gum  retarded the drug release up to 12 hours in the concentration of  300 mg (F8).The formulations prepared with HPMC K l00M were also retarded the drug release for more than 12 hours. Hence they were not considered. The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed first order mechanism of drug release.