Preparation and characterization of oral fast dissolving tablet containing glibenclamide

Abstract

The purpose of the study was to achieve rapid onset of action. Glibenclamide is an oral anti-diabetic agent used in the treatment of type-2 diabetes mellitus. The formulation (F1-F16) were developed by using design expert 11 version. Glibenclamide prepared b using direct compression method. 16 batches of fast dissolving tablet of glibenclamide were prepared by using cross carmellose sodium and xanthan gum in different concentration. All the formulation were evaluated for weight variation, hardness friability, thickness, in -vitro disintegration time, in-vitro dissolution time etc., and F3 showed the values within limits. Formulation F3 with cross carmellose sodium showed the less disintegration time (8 sec). In-vitro dissolution studies showed 98.34 %drug release at the end of 30 minutes.