Formulation of aceclofenac solid dispersion for solubility enhancement

Abstract

The Aceclofenac is adrug belongs to non-steroidal anti-inflammatory drug (NSAID) which is having anti- inflammatory and analgesic properties, and it is widely used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The most major problems with this drug is its low solubility in biological fluids, which results as poor bioavailability after oral administration. Thats why, solid dispersions (SDs) of aceclofenac were prepared using PEG6000 to increase its aqueous solubility. Aceclofenac SDs were prepared in 1:1, 1:2, 1:3, 1:4 and 1:5 ratios by kneading method and same ratio taken to prepare SDs prepared by solvent evaporation method too. In-vitro release profiles of all SDs (F-1 to F-5 by solvent evaporation method and FM-1 to FM-5 by kneading method) were comparatively evaluated and also studied against pure aceclofenac. Faster dissolution was exhibited by solid dispersion containing (1:5) ratio of drug: PEG6000 prepared by solvent evaporation method. The increase in dissolution rate of the drug may be due to increase in wettability, hydrophilic nature of the carrier and due to reduction in drug crystallinity. The prepared solid dispersion was subjected for percentage practical yield, drug content, infrared (IR).