Formulation and Evaluation of Sustained Release Albendazole Tablet

Abstract

The present focus is on the development of sustained release formulations due to its inherent boons. There are several advantages of sustained release drug delivery over conventional dosage forms like improved patient compliance, reduction in fluctuation of drug level in the blood and increased safety margin of potent drug. The present study was aimed to prepare a sustained drug delivery system of Albendazole. The sustained release matrix tablets of Albendazole were prepared by direct compression method and evaluated for different parameters such as weight variation, drug content, thickness, hardness, friability and In vitro drug release studies.  The in vitro dissolution study was carried out for 12 hours using USP (Type- II) paddle apparatus in hydrochloride (0.1N) as dissolution media for first 2 hours and phosphate buffer (pH 6.8) for next 10 hours. Based on the in vitro dissolution data, formulation F7 was selected as the best formulation from Albendazole formulations (F1 – F9) as the drug release was retarded up to 12 hours and followed zero order release kinetics & drug release mechanism was diffusion.