Synthesis and evaluation of some novel heterocyclic compounds containing Pyrimidine and Thiazolidinone rings and their Derivatives as an antimicrobial agents

Abstract

A  series  of  (4,  6-disubstituted  phenyl)  pyrimidine  and  their  derivatives  are  known  for  their  biological importance. In present research work, we have attempted both Conventional to synthesize 1- (4, 6-disubstituted phenyl) pyrimidin-2yl-2-(4methoxyphenyl) thiazolidine-4-one. A wide spectrum of biological activities like anti-diabetic, anti-bacterial, antifungal, anti-oxidant and anti-inflammatory activities are found to be associated with pyrimidine nucleus. Chalcones were synthesized by claisen -schmidt reaction using aromatic aldehydes and ketones. Then  reacting  with  guanidine  hydrochloride the  resultant pyrimidine compounds are  synthesized. Again its Schiff’s base reaction is carried out and then cycloaddition reaction is done, so (4, 6 -disubstituted phenyl) pyrimidin-2 yl-2-(4methoxyphenyl) thiazolidine-4-one derivatives are prepared by using thioglycolic acid. All the synthesized compounds were characterized by IR were recorded for all compo unds, 1H-NMR and Elemental Analysis was carried out for prototype of compounds. All the compounds were evaluated for antibacterial  (S.  aureus  and  E.  coli)  activity  and  antifungal  (A.  niger  and  C.  albicans)  activity  at  the concentration of 100 µg/mL by using cup-plate agar diffusion method. The activity was measured in terms of zone of inhibition and compared with standard drug Ciprofloxacin for antibacterial activity and Griseofulvin for antifungal activity.