Degradation Study of Different Brands of Moxifloxacin by UV-Spectroscopy

Abstract

Moxifloxacin is the wide range antibiotic effective against the (-ve) bacteria and (+ve) bacteria. The drug Shows maximum absorption at 293nm and obeys Beer-Lambert’s law. The forced degradation studies Conducted for the determination of degradation of durg product. According to ICH guide line moxifloxacin exposed to different Condition. Degradation amount of the drug product can be calculated with the help of UV Spectrophotometer. According to USP /BP the official test limits should not less then (%) and should not more then (%). On exposure to acidic and basic medium of Avelox, Izilone and Moxiget the forced degradation Studies Conducted. Observed negligible difference in availability on exposure to UV and heat during the forced degradation Studies of the drug substance. This method is simple, less time consuming and Cost effective. For the simultaneous quantitative analysis of the Avelox, Izilone and Moxiget this method also can be successfully employed.