Formulation and evaluation of oral dispersible tablets of aripiprazole

Abstract

An orally disintegrating tablet or orally dissolving tablet (ODT) is a drug dosage form available for a limited range of over-the-counter (OTC) and prescription medications. ODTs differ from traditional tablets in that they are designed to be dissolved on the tongue rather than swallowed whole. The ODT serves as an alternative dosage form for patients who experience dysphagia (difficulty in swallowing) or for where compliance is a known issue and therefore an easier dosage form to take ensures that medication is taken. Common among all age groups, dysphagia is observed in about 35% of the general population, as well as up to 60% of the elderly institutionalized population and 18-22% of all patients in long-term care facilities ODTs also have a faster onset of effects than tablets or capsules, and have the convenience of a tablet that can be taken without water. During the last decade, ODTs have become available in a variety of therapeutic markets, both OTC and by prescription. Oro-dispersible tablet refers to tablet which easily. Our objective is to formulate and evaluate the oro-dispersible tablets an anti-psychotic drug. The formulation is optimized by incorporating varying composition of polymers such as Manitol, Micro crystalline cellulose and  Povidone. All  the  excipients are  tested  for  compatibility with  model  drug.  The  pre-formulation parameters such as Tapped density, Bulk density, Compressibility index, Hausner’s ratio and Angle of repose were analyzed. The Thickness, Hardness, Friability, Disintegration time, Weight variation and Content uniformity was evaluated for core tablets. The In-vitro drug release was performed by using dissolution apparatus-II (USP paddle type) by maintaining temperature of 37oC ± 5oC. Based on the dissolution result B6  formulation (containing cross povidone) was selected as best formulation. The drug release of B6  follows zero-order. The total amount of drug released from the B6 is the maximum and it reached to about 85.39%