Formulation and evaluation of colon specific drug delivery system containing ketorolac microsponge oral tablet

Abstract

The present study was mainly aimed to formulate the Ketorolac loaded microsponge based colon targeted tablet for treatment of colon specific disease. The major excipient used in this study was Eudragit S-100, and polymeric microsponges were utilized for delivery of drug. The drug was loaded into microsponges those were fabricated by using quasi emulsion solvent diffusion technique and hence evaluated for different parameters like, particle size, production yield, entrapment efficiency, surface morphology and micromeritics properties in orderly. The evolution results were shown that good production yield, drug entrapment efficiency and spherical morphology. Later the microsponge based tablet was also prepared by using direct compression method along using the excipients like, lactose and then evaluated with respect to drug content and in-vitro drug release kinetics as well. The formulation were showed desirable amount of drug (more than 90 %). The drug release of formulation shows zero order kinetics with diffusion-controlled mechanism. That why the present study can be considered as a novel approach for colon targeted delivery of Ketorolac.