Preparation and evaluation of controlled release tablets containing lornoxicam

Abstract

The aim of study was to prepare controlled release tablets of Lornoxicam using HPC 2M, HEC 2M and HPMC K 15M polymer. Tablets were formulated by direct compression technology employing the polymer in different concentrations (4, 8, 12 and 16). The prepared batches were evaluated for drug weight variation, thickness, hardness and subjected to in vitro drug release studies. Among all the formulations F10 formulation showed maximum % drug release i.e., 98.41 % in 12 hours  hence it is considered as optimized formulation F10 which contains HPMC K 15M (8mg). Whereas the formulations with HPMC K 15M showed more retarding with increasing concentration of polymer. In vitro drug release data were fitted in various release kinetic models for studying the mechanism of drug release. The drug release from the matrix tablets was found to follow peppas models.