Number of leukosits in patients of nasopharynx cancer after radiotherapy Retrospective Case Study: Nasofaring Cancer in Radiotherapy Installation of Sanglah Hospital

Abstract

Radiotherapy is a way to cure or reduce pain in patients with tumors or cancer by using ionizing radiation. One type of cancer that is quite commonly experienced by cancer sufferers in Indonesia is nasopharyngeal cancer (NPC). This study aims to determine the effect of radiotherapy irradiation on human organs, especially in white blood cell types of leukocytes which are the most sensitive blood cells to radiation. This type of research uses quantitative research and uses retrospective data. Data collection in this study was carried out at Sanglah Hospital Radiotherapy Installation Denpasar. The population of this study were all nasopharyngeal cancer patients who underwent radiotherapy with the study sample including thirty nasopharyngeal cancer patients who underwent radiotherapy irradiation for the period 2018-2019. The study was conducted by recording the number of leukocytes from the results of the patient's complete blood laboratory. The data is then processed using SPSS, namely Pearson correlation test and linear regression test. The results of the study using the Pearson correlation test obtained a significant value of 0.002 (p-value <0.05) then there is the effect of radiotherapy irradiation on the number of leukocytes in nasopharyngeal cancer patients Linear Regression Test also shows the coefficient value of -0.371, the longer the radiation radiotherapy the number of leukocytes will decrease, while the value of 0.371 indicates that the correlation value is low which means the number of leukocytes in nasopharyngeal cancer patients decreases less sharply due to radiotherapy.