Taste masking and improvement of anti microbial activity of cefuroxime axetil oral suspension

Abstract

Cefuroxime axetil is a second generation cephalosporin antibiotic active against wide range of organisms, which is a
prodrug of Cefuroxime. Cefuroxime axetil is extremely bitter in taste, which reduces the patient compliance when
taken as oral suspension especially in pediatric population. The objective of this study was to mask the bitter taste of
Cefuroxime axetil using Hydroxy propyl betacyclodextrin [HP- Betacyclodextrin] by inclusion complexation method
and to evaluate the improvement in antimicrobial activity of oral suspension, compared to a leading marketed
product.