Eco-friendly synthesis and characterization of zinc oxide nanoparticles loaded with cinchona officinalis bark extract as potent antibacterial activity

Abstract

Today nanotechnology has been emerging in different scientific fields, with its synthesis, characterization, and applications. Nanoparticles are hollow structures with cavities or pores that trap small molecules. In the present study, cinchona officinalis bark was investigated for its potential to synthesize zinc oxide nanoparticles. The synthesis of nanoparticles was confirmed by the change in colour of the reactant solution from yellow to white. The resultant solution was characterized by UV -Visible spectroscopy where the absorption peak was absorbed at 234nm. Fourier transform (FT-IR) spectroscopic analysis shows an absorption peak at 500-4000cm^-1. XRD pattern shows the crystallinity and relative intensity of the drug. From SEM analysis ZnO nanoparticles are agglomerated form. The study of anti-bacterial potential was carried out by using the agar well diffusion method, which indicates the ZnO nanoparticles exhibit good potential as a bactericidal.