Formulation and evaluation of sulfasalazine tablets for colon targeting using 33 response surface method
DOI:
https://doi.org/10.61096/ijpar.v6.iss4.2017.618-634Keywords:
Sulfasalazine, Colon targeting, Crohn's disease, Eudragit, pH dependent polymers.Abstract
The aim of the study was to develop colon targeted tablets of Sulfasalazine (SSZ) by wet granulation method using 33 Response surface method with Design of experiment software and Eudragit RS 100, Eudragit RL 100 -55, Ethyl cellulose and PVP K-30 as pH dependent polymers. All the formulations (F1 to F27) were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Sulfasalazine released from tablets at different time intervals was estimated by UV spectrophotometer. The formulation F17 shown 98.21±1.15 of Sulfasalazine after 24h, where as marketed product drug release was 96.21±1.87 after 1 h. The results of the study showed that formulation F17 is the best formulation on the basis of drug release and other evaluation parameters and the pH dependent tablet system is a promising vehicle for preventing rapid hydrolysis in gastric environment and improving oral bioavailability of Sulfasalazine for the treatment of disease at colon region.