Formulation & evaluation of colon targeted drug delivery system of omeprazole

Abstract

The purpose of the present study was to formulate colon delivery tablets of Omeprazole, an Anti-ulcer agents. Omeprazole tablets were prepared by direct compression method employing rate controlling the synthetic polymer Eudragit RSPO, Eudragit RLPO  The Prepared granules were subjected for pre compressional and drug excipient compatibility studies  and  tablets  were  evaluated  for  post  compressional parameters  such  as  weight  variation, hardness, friability, drug content, and Invitro dissolution studies. It was concluded that the out of all the  formulations F12 was the best formulation as the extent of drug release was found to be 96 % upto 24 hrs  and the kinetics of drug release was follows first order kinetics with the „n‟ value of more than 0.5 indicates that non-fickian mechanism. % Cumulative drug release from all the prepared formulation was found to be in following order F12>F11>F10>F9>F8>F7>F6>F5>F4>F3>F2>F1 The  kinetics  of  optimized  formulation F12  was  found  to  be follows first order kinetics and the „n‟ is more than 0.5 indicates that it follows non-fickian mechanism. Endured super case II release, during the dissolution study, which indicated that polymer relaxation, had a significant role in the drug release mechanism. Drug release mechanism was case II non-Fickian (anomalous) release (0.5≤ n ≤ 0.89).