Formulation And Evaluation Of Immediate Release Tablets Of Valsartan By Using Millet Starch As Disintegrant

Abstract

The immediate release tablet of antihypertensive drug Valsartan were prepared and evaluated to increase solubility and bioavailability of low soluble drug. Immediate release tablet of valsartan prepared by using polymer such as Millet starch (9%), Millet starch (12%), Sodium starch glycolate, L-HPC, Pregelatinized starch by using direct compression technique. The immediate release tablets were evaluated for physicochemical parameter like thickness, hardness, weight variation, friability and in-vitro drug release. The in-vitro drug release studies were found that optimized formulation F4 show immediate drug release within 10 minutes up to 98.64%. From the above study it was concluded that all formulations F1-F9 in that F4 formulation was optimized for further in vivo studies.