New Developed and Validated, Rapid HPLC Method for the Determination of Rosuvastatin Calcium and Fenofibrate Simultaneously in Combined Tablet Dosage Form.

Authors

  • Marati Shashikanth Omega College of Pharmacy, Edulabad, Ghatkesar, Affiliated to Osmania University, Hyderabad, Telangana, India.
  • A.V. Jithan Omega College of Pharmacy, Edulabad, Ghatkesar, Affiliated to Osmania University, Hyderabad, Telangana, India.
  • H.Parameshwar Omega College of Pharmacy, Edulabad, Ghatkesar, Affiliated to Osmania University, Hyderabad, Telangana, India.

DOI:

https://doi.org/10.61096/ijpar.v11.iss4.2022.353-359

Keywords:

HPCL, Fenofibrate, Rosuvastatin Calcium, Validation

Abstract

A new developed and validated  simple ,precise, accurate, and rapid HPLC method for the determination of rosuvastatin calcium and  fenofibrate simultaneously, in combined tablet dosage form the mobile phase used was a mixture of 1% TEA : Acetonitrile  (60:40%v/v), PH: 5.8. the detection of rosuvastatin calcium and fenofibrate was carried out at 287 nm with a flow rate of 1.0ml/min. The retention time (min) for rosuvastatin calcium and fenofibrate were 2.7, 4.28 respectively. Results of the analysis were validated statistically, and by recovery studies. The proposed method can be successfully used to determine the drug contents of marketed formulation.

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Published

2022-10-13

How to Cite

Marati Shashikanth, A.V. Jithan, & H.Parameshwar. (2022). New Developed and Validated, Rapid HPLC Method for the Determination of Rosuvastatin Calcium and Fenofibrate Simultaneously in Combined Tablet Dosage Form. IJPAR JOURNAL, 11(4), 353–359. https://doi.org/10.61096/ijpar.v11.iss4.2022.353-359