New Developed and Validated, Rapid HPLC Method for the Determination of Rosuvastatin Calcium and Fenofibrate Simultaneously in Combined Tablet Dosage Form.
Keywords:HPCL, Fenofibrate, Rosuvastatin Calcium, Validation
A new developed and validated simple ,precise, accurate, and rapid HPLC method for the determination of rosuvastatin calcium and fenofibrate simultaneously, in combined tablet dosage form the mobile phase used was a mixture of 1% TEA : Acetonitrile (60:40%v/v), PH: 5.8. the detection of rosuvastatin calcium and fenofibrate was carried out at 287 nm with a flow rate of 1.0ml/min. The retention time (min) for rosuvastatin calcium and fenofibrate were 2.7, 4.28 respectively. Results of the analysis were validated statistically, and by recovery studies. The proposed method can be successfully used to determine the drug contents of marketed formulation.