Formulation and in vitro evaluation of liquisolid compacts of telmisartan

Abstract

Telmisartan is Angiotensin receptor blocker, ARB used for the treatment of the Hypertension. This drug is poorly soluble in water that causes slow dissolution rate of the drug and also slow absorption which eventually leads  to  the  inadequate and  low oral  bioavailability[4] i.e.,  43%. To  overcome this  problem the  drug  is formulated with the most novel technology the Liquisolid compaction. In this technology, the insoluble drug is made dissolved in the suitable non-volatile water miscible solvent to form the drug solution which is then compressed directly into the Liquisolid tablets  by the addition of suitable carrier and coating materials along with the lubricant, glidant, and disintegrants.   In this study, Neusilin, the widely accepted multifunctional excipient is used in the formulation of telmisartan compacts .Neusilin is the synthethic granule of magnesium alumina metasilicate.