Formulation and in vitro evaluation of liquisolid compacts of telmisartan
DOI:
https://doi.org/10.61096/ijpar.v6.iss4.2017.692-696Keywords:
Telmisartan, Neusilin, Liquisolid tablets[10].Abstract
Telmisartan is Angiotensin receptor blocker, ARB used for the treatment of the Hypertension. This drug is poorly soluble in water that causes slow dissolution rate of the drug and also slow absorption which eventually leads to the inadequate and low oral bioavailability[4] i.e., 43%. To overcome this problem the drug is formulated with the most novel technology the Liquisolid compaction. In this technology, the insoluble drug is made dissolved in the suitable non-volatile water miscible solvent to form the drug solution which is then compressed directly into the Liquisolid tablets by the addition of suitable carrier and coating materials along with the lubricant, glidant, and disintegrants. In this study, Neusilin, the widely accepted multifunctional excipient is used in the formulation of telmisartan compacts .Neusilin is the synthethic granule of magnesium alumina metasilicate.