Development and validation of the quantitative analysis of lisinopril dihydrate in tablet formulation by fourier transform infrared spectroscopy
DOI:
https://doi.org/10.61096/ijpar.v6.iss4.2017.697-704Keywords:
Fourier Transform Infrared Spectroscopy, Quantitative Determination, Quality Control, Lisinopril Dihydrate.Abstract
A simple, precise, non accurate, rapid, inexpensive, ecofriendly and reproducible FTIR spectrophotometric method for quantitative determination of lisinoprildihydrate in tablet formulation was developed and validat ed. This method concerned with measurement of absorbance measurements of bands corresponding to OH stretch centered by 3625-3490 cm-1. Analytical method validation was carried out to study the parameters as linearity, repeatability, precision and accuracy. The linearity range was found to be 0.3 -1.8 % w/w (regression equation: y=0.300x-0.030, r2 = 0.994). The data show good precision results of this method, since the RSD values observed less than 2 %. The proposed FTIR method was successfully applied to the assay of lisinoprildihydrate in bulk drugs and tablet formulation.