Development and validation of the quantitative analysis of amlodipine besylate in tablet formulation by fourier transform infrared spectroscopy

Abstract

A   simple,   precise,   non   destructive,   rapid,   and   inexpensive,   ecofriendly   and   reproducible   FTIR spectrophotometric method for quantitative determination of amlodipine besylate in tablet formulation was developed and validated. This method concerned with absorbance measurements of bands corresponding to c=o stretch centered by 1731-1687 cm-1. Analytical method validation was carried out to study the parameters as linearity, repeatability, precision, accuracy as well as photo degradation study. The linearity range was found to be 0.3-1.8 % w/w (regression equation: Y=0.585x-0.044, r2  = 0.994). The data show good precision results of this method, since the RSD values observed less than 2 % as per ICH limits. The proposed FTIR m ethod was successfully applied to the assay of amlodipine besylate in tablet formulation.