Development and validation of UV- spectrophotometric method for the estimation of dabigatran etexilate mesylate (dem)

Authors

  • U.Harini Department of Pharmaceutical Analysis & Quality Assurance, A. U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.
  • N. Madhavi latha Department of Pharmaceutical Analysis & Quality Assurance, A. U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.
  • A.K.M Pawar Department of Pharmaceutical Analysis & Quality Assurance, A. U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

DOI:

https://doi.org/10.61096/ijpar.v5.iss1.2016.218-223

Keywords:

UV-Visible Spectrophotometer, Dabigatran Etexilate Mesylate, ICH guidelines.

Abstract

Objective

To develop and validate a  simple, accurate, precise and cost effective UV-Spectrophotometric method for the estimation of Dabigatran Etexilate Mesylate (DEM).

Method

UV spectrophotometric method was performed at 226 nm and the samples were prepared with methanol as solvent.

Results

Linearity range was found at 2-10µg/ml in UV with correlation coefficient (R) 0.999 and the regression equation is y

= 0.066x + 0.012.

Conclusion

The proposed methods were simple, precise, Accurate and can be used for the analysis of drug in bulk form.

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Published

2016-03-05

How to Cite

U.Harini, N. Madhavi latha, & A.K.M Pawar. (2016). Development and validation of UV- spectrophotometric method for the estimation of dabigatran etexilate mesylate (dem). IJPAR JOURNAL, 5(1), 218–223. https://doi.org/10.61096/ijpar.v5.iss1.2016.218-223

Issue

Vol. 5 No. 1 (2016): 2016 Volume - 5 Issue - 1

Section

Articles