Formulation and evaluation of fluconazole and ichthammol ointment

Abstract

The fluconazole drug is used for treatment of anti-fungal infections like eczema, itching, pruritis. Reason for this study to formulate the ointment with different ointment bases.The ointment bases having good consistency, better diffusion, anti-fungal and antiseptic properties.  Combination of fluconazole and i chthammol is used to treat  the  infection  caused  by  coryne  bacteria.  Fluconazole  and  ichthammol  having  good  anti -fungal  and antiseptic property respectively. So it is used to cure the skin infection on the epidermis layer. The prepared formulation is evaluated for assay drug release, uniformity, viscosity, diffusibility, stability, permeability and other  physical  characteristics. Two  formulations,  formulation  F1  and  F2  were  prepared  with  same  active ingredients except different bases. Formulation F1 contains white soft paraffin, cetostearyl alcohol, light liquid paraffin and microcrystalline wax. Formulation F1 was found better than formulation F2 in all aspects like viscosity, stability, diffusibility etc.