Antihyperlipidemic potential of roots of bauhinia tomentosa in High-fat diet fed rats

Abstract

The present study was designed to investigate antihyperlipidemic activity of ethanolic & aqueous extract of roots of Bauhinia Tomentosa (EEBT & AEBT). High fat diet was prepared and the treatment schedule was followed for the respective group of animals for 40 days. Daily all the animals were given high fat diet with drug treatment of aqueous and ethanolic root extracts of Bauhinia tomentosa. After 40 days the antihyperlipidemic parameters were evaluated. The EEBT & AEBT significantly reduced lipid profile (TC, TGL, LDL and VLDL) and increased HDL level.  EEBT and AEBT both 200 mg/kg and 400 mg/kg and standard drug exhibited significant decrease in blood sugar and total protein. EEBT at 200 mg/kg and 400 mg/kg and standard drug showed significant Increase in SGOT levels, AEBT at 400mg/kg/p.o  showed significant  decrease in SGOT levels. The EEBT  and AEBT  at dose levels 200 mg/kg/p.o showed significant decrease in SGPT levels. At two dose levels the extract showed significant increase in serotonin levels in HFD fed rats. It could be predicted that Bauhinia tomentosa root extracts exerted significant hypolipidemic effect along with hypoglycemic and in rats fed on high fat diet.