Chronotherapeutics drug delivery system: A promising approach to treat hypertension

Abstract

The  circadian  rhythm  of  mammals exists  in  the  suprachiasmatic  nuclei  (SCN)  and  influences  an  assembly  of  biological processes, including the sleep-wake rhythm. Clock cycles are the genes that control the circadian rhythms in physiology and behavior of the mammals. Circadian rhythm has been proved for the function of physiology and the pathophysiology of diseases. The effectiveness and adverse toxicity of many drugs vary depending on dosing time.   The Novel technology for delivering medications surely in a time-dependent is being developed to manage certain  diseases.  Chronopharmaceutics  is  a  branch  of  pharmaceutics  keen  to  the  design  and  evaluation  ofdrug delivery system that release a active pharmaceutical agent at a rhythm that preferably matches in realtime for the biological requirement of a given disease therapy.