Analytical Method development and validation for the Estimation of Dasatinib by Using RP—HPLC Method

Authors

  • R.Vani Department of Pharmaceutical Analysis, Shadan Women’s College of Pharmacy, Khairatabad, Hyderabad.
  • FouZia Jabeen Department of Pharmaceutical Analysis, Shadan Women’s College of Pharmacy, Khairatabad, Hyderabad.

DOI:

https://doi.org/10.61096/ijpar.v9.iss4.2020.264-269

Keywords:

Dasatinib, HPLC, Method development, Linearity, Validation

Abstract

A simple and precise method was developed for estimating Dasatinib. The method was found to be specific and precise. The separation was attained on Acquity CSH C18 Column (150*2.0mm & 1.5µm) and linearity was achieved in the concentration rage of 50µg/ml to 250µg/ml of Dasatinib with correlation coefficient 0.99. The percent recovery from the assay was found to be 99.79% for Dasatinib. Limit of detection and quantitation for Dasatinib were within the acceptable range. From the stability studies, the percentage variation was less than 10.0% which is the desired criteria. Therefore, this method can be adopted to estimate Dasatinib in other pharmaceutical formulations.

 

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Published

2020-11-18

How to Cite

R.Vani, & FouZia Jabeen. (2020). Analytical Method development and validation for the Estimation of Dasatinib by Using RP—HPLC Method. IJPAR JOURNAL, 9(4), 264–269. https://doi.org/10.61096/ijpar.v9.iss4.2020.264-269

Issue

Vol. 9 No. 4 (2020): 2020 Volume - 9 Issue - 4

Section

Articles