Formulation and evaluation of lornoxicam of sustained release matrix tablets

Abstract

The major objective of the present research work is to prepare and evaluate sustained release matrix tablets of lornoxicam
using hydroxyl propyl methyl cellulose (HPMC K15M). It is practically insoluble in water and aqueous fluids. Sustained
release formulation is needed for lornoxicam because of its short biological half-life of 3.0-5.0 h. To study and evaluate
the effect of two solubilizers namely polyvinyl pyrollidine PVP K30 and poly ethylene glycol (PEG 400) on the aqueous
solubility of lornoxicam. Lornoxicam sustained release matrix tablets were formulated by employing hydroxyl propyl
methyl cellulose (HPMCk15M) as matrix former, poly ethylene glycol (PEG400) as solubilizer, lactose or dicalcium
phosphate as diluent for lornoxicam by wet granulation process. All the tablets prepared were evaluated for hardness,
disintegration time and dissolution rate. Lornoxicam SR tablet equivalent 220 mg was used in each case. The solubility of
lornoxicam was found to be 4.36, 40.76, and 38.36 mg/100ml respectively in water and water containing 2% PEG 400 and
2% PVP. Formulations F1, F2, F3, and F4 contain 50% HPMC K15M as release retardant. Formulations F1 and F2
contain lactose and DCP respectively as diluents, Formulations F3 and F4 contain PEG 400 at 5% strength as solubility
enhancer, Tablets containing lactose as diluent gave relatively rapid release when compared to those containing DCP. All
Formulations F1-F4 gave very slow release, about 20-35% in 24 hrs diluent. Formulations F5 and F6 were prepared
employing HPMC K15M. Drug release from these formulations was very rapid and complete within 6 h in the case of F5
and within 10 h in the case of F6. Formulations F7 and F8 were prepared using 25% and 40% HPMC K15M, Lornoxicam
release from the commercial SR tablets was slow and extended over a period of 18-20 h. Lornoxicam release from
formulation F7 was slow and spread over 16 h. Drug release from formulation F7 was nearly similar to that from
commercial formulation. Hence formulation F7 is considered as the best SR formulation of Lornoxicam. The FTIR spectra
of lornoxicam and its formulated tablets in HPMCK15M, lactose and DCP were obtained with FTIR Spectrophotometer.