A Review on Multilayer Tablets

Abstract

Oral drug delivery has been known for decades as the most widely utilized route of administration among all routes
that have been explored for the systemic delivery of drugs in case of different dosage forms. Multilayer tablets are
tablets made by compressing several different granulations fed in to a die in succession, one on top of another, in layer.
Each layer comes from a separate feed frame with individual weight control. Rotary tablet presses can be set up for 2 or 3
layers. More are possible but the design becomes very special. Ideally a slight compression of each layer and individual
layer ejection permits weight checking for control purposes.