Formulation and evaluation of chitosan-based hydrogel matrix of licorice for targeting helicobacter pylori

Abstract

In present investigation an attempt has been made to formulate and evaluate chitosan-based hydrogel of matrix of Licorice for targeting Helicobacter pylori. Licorice was evaluated for its physical characteristics, analytical profiles and drug polymer compatibility study. The prepared Hydrogel granules were evaluated for pre-formulation characteristics like Angle of  repose, Bulk density, Tapped density and  Carr’s index. The results obtained were found to be satisfactory and within the specified limits. A Stomach retentive licorice loaded chitosan hydrogel was prepared successfully by chemical crosslinking method. Glutaraldehyde was used  as  chemical  crosslinking  agent.  After  compression  parameters  like  Thickness,  Hardness,  Weight variation, Friability, content  uniformity  and  In-Vitro  release  studies  were  evaluated. Mucoadhesive study showed that, licorice loaded hydrogel have good mucoadhesion property and retained in gastric environment of stomach for prolonged period of time. The results of In-vitro studies showed that by chitosan concentration the extent of swelling and rate of drug release can be modulated. In the present study the effect of concentration of polymer are studied through In-Vitro drug release.