Crystal investigation and characterization of the pseudopolymorphic forms of gemifloxacin mesylate


  • Ganesan V
  • Ethiraj T


Gemifloxacin meyslate, Pseudo polymorph, FTIR, PXRD, SEM


Main objective of this present study was to prepare and investigate the different pseudo polymorphic forms of
gemifloxacin using Powder X-Ray Diffraction analysis (PXRD), Scanning Electron Microscopy (SEM), Differential
Scanning Calorimetry (DSC), Fourier Transform Infrared Spectrometry (FTIR) and dissolution studies. For this purpose,
crystals of gemifloxacin (G-1 to G-4) were obtained by solvent evaporation method using various solvents like
isopropanol, chloroform, dichloromethane and benzene and characterized. Pseudo polymorph obtained from isopropanol
(G-I) showed highest solubility and percentage drug release than others. The existence of different polymorphic forms of
gemifloxacin has been proved by appearance and disappearance of peaks on the PXRD graph and melting points of each
at different temperature. It was concluded that the gemifloxacin existed four pseudo polymorphic forms and showed
highest percentage drug release than the amorphous form.