Formulation and invitro evaluation of nystatin organo gels

Abstract

The purpose of topical dosage form is to conveniently deliver drug across a localized area of the skin. To develop an
ideal dosage form, one must take into account flux of the drug across the skin, nature of drugs, patient acceptability of
the formulation, etc.., Nystatin is categorized as synthetic allylamine antifungal drug and is successfully used to
treat Fungal disorders. On this contest, emulgel was formulated using carbopol 934 and HPMC, liquid paraffin
as oil phase, emulsifying agents like tween 20 and span 20 and propylene glycol as permeation enhancersOn
basis of quality of organogels produces total eight formulations F1 to F8 were selected. They were evaluated for
physical appearance, pH, rheological study, spreadability, drug content and in-vitro drug permeation study.
Thus, the formulated organogel had a distinct advantage over existing conventional dosage form in that the drug
permeation was found to be rapid across the skin and hence the increased therapeutic response by bypassing 1st
pass metabolism and with no gastrointestinal problems and patient compliance.