Formulation and in vitro evaluation of candesartan liquid solid compacts to enhance drug solubility

Abstract

liquisolid compacts were prepared by using PEG 400, propylene glycol as the nonvolatile liquid vehicles. Avicel
PH 102 and Aerosil were used as the carrier and coating material, respectively. From the results obtained from
executed experiments, it can be concluded that the preformulation studies like melting point, flow properties
of Candesartan were compiled with IP standards. The FTIR spectra revealed that, there was no
interaction between polymer and drug. Polymers used were compatible with Candesartan. Among the PG in
1:3 ratio (F7) was showing best release. Stability studies showed that there were no significant changes in
physical and chemical properties of tablet of formulation F7 after 3 months. This research work has produced
encouraging results in terms of increasing the in vitro dissolution of poorly soluble drugs such as Candesartan
using liquisolid technology. The technique being simple and effective can also be extended to other
poorly soluble drugs. The in vivo performance of the liquisolid compacts has to be studied using animal
models to claim a complete success in the development of these formulations.