Formulation and evaluation of oro-dispersible tablets of ivabradine by sublimation technique

Abstract

who have trouble in swallowing tablets. The objective of the present study was to prepare the mouth disintegrating tablet
of ivabradine. Tablets of drug were prepared by sublimation method or technique. In the formulation of ivabradine oro
dispersible tablets, initially ivabradine fused with cross Carmellose sodium (optimized super disintegrate), is used as API
and sublimating agent menthol were added to the formulation, results showed that 99% was released in 15min in
formulation (F7), and 94% was released in 30min from the formulation containing super disintegrant Cross povidone (F8),
and 95% was released in 30min from the formulation containing super disintegrant sodium starch glycolate (F9). In
formulation F7, the super disintegrant CCS (15%) and sublimating agent menthol (10%) was added and 99% was released
in 15min, which is the highest amongst all and hence this is finalized. All these tablets showed required hardness, limited
friability and good disintegration time (with in IP and USP limits). All the formulations were evaluated for drug content
and results are obtained. Amongst all formulations, formulation F7 and CCS as super disintegrant showed the least
disintegration time and faster dissolution.