Novel approaches in solid lipid nano particles and drug targetting

Abstract

Solid lipid nanoparticles are at the new wave of the rapidly developing field of nanotechnology with several
potential applications in drug delivery, clinical medicine and research as well as in other varied sciences. Due to
their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. By
putting forward physiological safe lipids in place of polymers to prepare lipid nanoparticles, a novel
formulation technique came into light. The ability to incorporate drugs into nanocarriers offers a new prototype
in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid
nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence
have attracted wide attention of researchers. In addition, wide pharmaceutical applications of SLNs in drug
delivery are explored. Diverse instrumental techniques have been highlighted to characterize the
physiochemical properties of SLNs. various routes of administration of SLNs as drug carriers are logistically
reviewed and discussed. The different types of nanocarriers which were based on solid lipid like solid lipid
nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their structural differences.
Different production methods which are suitable for large scale production and applications of solid lipid
nanoparticles are described and aspects of solid lipid nanoparticles route of administration and their
biodistribution are also incorporated. SLNs may open new vistas in therapy of complex diseases like cancer.