A new validated RP-HPLC method for the analysis of Bempedoic acid and Ezetimibe in bulk drug samples
DOI:
https://doi.org/10.61096/ijpar.v9.iss4.2020.248-252Keywords:
bempedoic acid, ezetimibe, Validation, RP-HPLC.Abstract
A short selective, precise, accurate and sensitive for the estimation of bempedoic acid and ezetimibe was done by RP-HPLC. The chromatographic separation was clear at the flow rate of 1 ml/min, at UV detection of 232 nm. The assay for bempedoic acid and ezetimibe were found to be 99.95 and 100.24 respectively. which shows that the method is useful for routine analysis. The linearity of bempedoic acid and ezetimibe was found to be direct with a relationship coefficient of 0.999 and 0.999, which appears that the strategy is competent of creating great affectability. The LOD and LOQ for bempedoic acid was found to be 2.9 and 10.03 and LOD and LOQ for ezetimibewas found to be 3.0 and 10.1. The vigor restrain for versatile stage variety and stream rate variety are well inside the constrain, the % debasement comes about are in limits. Which appears that the strategy is having great framework reasonableness and accuracy beneath given set of conditions. From the recovery and the studies, showing acceptable limits, it can be concluded that this can be employed for estimation of bempedoic acid and ezetimibe in its dosage forms.
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