Method development and the Simultaneous estimation of Escitalopram and L-methylfolate in tablet dosage form by RP-HPLC Method

Abstract

Analytical Chemistry seeks ever-improved  means of measuring the chemical composition of natural and artificial materials. The techniques  of this science are used to identify the substances,  which may be present in a material,  and to determine  the exact amounts  of the identified  substances.  Analytical  chemists  work  to improve  the  reliability  of existing  techniques  to meet  the demands for better chemical measurements, which arise constantly in our society. They adapt proven methodologies to new kinds of materials  or to answer  new questions  about their composition.  Escitalopram  is one of a class of antidepressants  known  as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. L-methylfolate is the only metabolite of folate that can cross the blood-brain barrier, and it is this form that can directly impact several important CNS  reactions,  most  notably  the  synthesis  of  three  important  neurotransmitters:   serotonin,  norepinephrine,  and  dopamine. Simultaneous  estimation  of  Escitalopram  and  L-methylfolate  in  tablet  dosage  form  by RP-HPLC  Method.  The  method  was validated as for ICH guidelines and it can be used for the routine analysis of Escitalopram  and L-methylfolate  in tablet dosage form.