Development of a novel UV spectrophotometric method for the estimation of lacosamide in both bulk and solid dosage forms

Abstract

The present study aims to develop a simple, precise and accurate UV spectrophotometric method for the estimation of Lacosamide in both bulk and in pharmaceutical dosage form. From the solubility profile, phosphate buffer with pH 3 was chosen as a solvent for the estimation of Lacosamide by ultraviolet spectroscopy. From the spectra, Lacosamide showed maximum absorbance at 210 nm.The proposed method was validated in accordance with the ICH guidelines and successfully applied for the tablet formulation. The percentage label claim present in tablet formulation was found to be 99.08 ± 0.6568%. The percentage recovery was found to be in the range of 99.06 ± 0.5386 %. From the high recovery values (> 98%) it can be inferred that the method is free from the interference of excipients used in the formulation. Based on the results obtained, the proposed method can be regarded as simple, accurate, precise, reliable and cost effective which can be employed for routine quality control of Lacosamide in tablet dosage forms.