Design, Synthesis and Evaluation of Diphenyl ether Derivatives as Antitubercular and Antibacterial Agents

Abstract

A new series of diphenyl ether derivatives were synthesized from meta phenoxy benzaldehyde and aniline. The synthesized compounds were screened for in-vitro antimycobacterial, antibacterial and cytotoxicity studies. The synthesized compound 2a have shown potential activity against Mycobacterium tuberculosis H37Rv strain with MIC 12.5. These  diphenyl  ether  derivatives  were  subjected  to  docking  studies  and  virtual  screening. The  receptor specificity of  the  synthesized compounds were  shown  from the  antibacterial activity study since  none  of  the synthesized compounds showed activity, so it have been proved that newly synthesized compounds were specifically act on the enoyl acyl carrier protein receptor.