Stability Indicating Analytical method development & Validation of 2, 4 - dihydroxy-5- Fluoro Pyrimidine in bulk drugs & its Injection formulation

Authors

  • S.Imampasha Department of Pharmaceutical Analysis & Quality Assurance, Sultan-Ul-Uloom College of Pharmacy, Banjara Hills, Hyderabad-500034, TS, India
  • Mohd. Ibrahim Department of Analytical Chemistry, Nizam Institute of Pharmacy Research Centre, Nalgonda T.S India
  • V.Murali Balaram Department of Pharmaceutical Analysis & Quality Assurance, Sultan-Ul-Uloom College of Pharmacy, Banjara Hills, Hyderabad-500034, TS, India

DOI:

https://doi.org/10.61096/ijpar.v5.iss4.2016.650-657

Abstract

Stability indicating HPLC method is developed for 2,4-dihydroxy-5-fluoropyrimidine bulk drug and its formulation, all validation parameters including specificity (interference, forced degradation), Precision (system, method, intermediate), Linearity, accuracy, range ,robustness studied, forced degradation (acid, base, peroxide, water, thermal ,humidity,  photo  stability  effect  studied  for  2,4-dihydroxy-5-fluoropyrimidine,Retention time  was  found  to  be 3.4minutes at the wave length of 254nm.

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Published

2016-12-16

How to Cite

S.Imampasha, Mohd. Ibrahim, & V.Murali Balaram. (2016). Stability Indicating Analytical method development & Validation of 2, 4 - dihydroxy-5- Fluoro Pyrimidine in bulk drugs & its Injection formulation. IJPAR JOURNAL, 5(4), 650–657. https://doi.org/10.61096/ijpar.v5.iss4.2016.650-657

Issue

Vol. 5 No. 4 (2016): 2016 Volume - 5 Issue - 4

Section

Articles