Synthesis and screening of new 2-(2-oxoindoline-3-ylidene)-nPhenyl hydrazine carbothioamides

Abstract

The purpose of this work to prepare or to synthesize the little compound, 2-(2-oxoindoline-3-ylidene)-N-phenyl
hydrazine carbothioamide derivatives by adopting appropriate synthetic routes. Then Purification and
characterization of all the new compounds including those of intermediates by recrystallization from appropriate
solvents or by chromatographic techniques. And Characterization of the newly synthesized compounds by
physical and spectral methods (IR, 1HNMR & MASS). Finally evaluation of the new compounds for
antimicrobial activities by standard methods available in the literature. It is evident from literature that the
presence of the indole nucleus found to have various pharmacological activities like antimicrobial, anticonvulsant, MAO inhibitory, anticancer and psychotropic activities. The very fact that one of indole derivatives
(isatins) is potential synthon, for building synthetically a variety of chemical systems known for their broader
and pharmacological applications. In view of pharmacological significance of indole derivatives is planned to
synthesize some new indole derivatives containing thiosemicarbazides.