Tumor targeting and brain specific delivery and strategies: A review
DOI:
https://doi.org/10.61096/ijpar.v10.iss1.2021.47-53Keywords:
brain barrier, drug delivery to brain, tumor microenvironmentAbstract
Brain tumors represent one of the most challenging and difficult areas in unmet medical needs. Tumor- targeted and brain drug delivery systems, increase drug accumulation in the tumor region, and also reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatments. When brain-tumors exhibit numerous notable characteristics relative to tumors growing in peripheral tissues, potential targets based on continuously changing vascular characteristics and the microenvironment can be utilized to facilitate effective brain tumor-targeted drug delivery. In present review, we briery describe the physiological characteristics of brain tumors, including blood–brain/brain tumor barriers, the tumor microenvironment, and tumor stem cells. We are also discussing in review targeted delivery strategies and introduce a systematic targeted drug delivery strategy to overcome the challenges. A disturbing fact about the delivery of drugs to the CNS in the presence of a blood-brain barrier that has a tendency to impair the drug distribution and denotes the general barrier for the development of CNS drugs. Neuro-peptides and many more drugs which are hydrophilic in nature possibly will encompass the intricacy while passing the blood-brain barrier. The net amount of delivered drugs and their capability to gain access to the pertinent target sites are the main considering points for CNS drug development. In this review, we will discuss about methodologies for targeting site of brain.