Spectrophotometric methods for quantitative estimation of sertraline hydrochloride from tablet formulation

Abstract

Two simple and sensitive visible spectrophotometric methods have been developed for the quantitative estimation of
Sertraline Hydrochloride from its tablet formulation. The developed methods are based on formation of chloroform
extractable colored complex of drug with alizarin red and tropaeolin ooo. The chloroform extracted complex of drug
with alizarin red showed absorbance maxima at 425.0 nm and linearity was observed in the concentration range of 20-
90 µg/ml (method-I), with tropaeolin ooo showed absorbance maxima at 485.0 nm and linearity was observed in the
concentration range of 3-24 µg/ml (method-II). Results of analysis for both the developed methods were validated
statistically and by recovery studies.